ANDEXXA®

Senior Secured Debt$125 million

MAR 2019

ProductANDEXXA®

ANDEXXA® (recombinant coagulation factor Xa, inactivated-zhzo; formerly andexanet alfa), approved in May 2018, is a recombinant human Factor Xa molecule which binds to, and reverses the anticoagulation effect of, Factor Xa inhibitors, such as ELIQUIS® and XARELTO®. ANDEXXA® is the first and only drug indicated for treating patients who are also taking these Factor Xa inhibitors when reversal of anticoagulation is needed due to life-threatening or uncontrolled bleeding.

Background

Portola Pharmaceuticals Inc. (NASDAQ:PTLA) was looking to raise capital to further fund the commercial launch of ANDEXXA® and to provide financial flexibility. Non-dilutive financing was appealing to Portola as the company believed it’s share price was undervalued. HCR worked with with Athyrium Capital Management in making this investment.

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